Protein Details: Potassium voltage-gated channel subfamily D member 1

Protein ID

ICDB_Pro_0646

Protein Name

Potassium voltage-gated channel subfamily D member 1

Gene Name

KCND1

Organism

Oryctolagus cuniculus (Rabbit)

Length

178 amino acids

AlphaFoldDB

AF-P59994-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits

Sequence

AKSGTTNAFLQYKQNGGLEDNGSGEEQALCVRNRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTSRSTSVSSQPVGPSSLLSSCCPRRAKRRAIRLANSTASVSRGSMQELDTLAGLRRSPGPQSRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in carotid body chemoreceptor cells and in frontal cortex.

DOI ID

10.1113/jphysiol.2002.018382